Post-surgical corneal damage

Often ocular conditions make surgical interventions necessary. However, ocular surgery (such as refractive surgery, cataract surgery and corneal transplant) can induce or exacerbate dry eye after surgery[1].

The surgical removal of corneal tissue, for example precipitated by excimer laser exposure for refractive purposes, causes a loss of nerve from the corneal stroma. Consequently, a reduction in corneal sensitivity is induced which provokes a decrease in reflex lachrymation and blinking. The purpose of reflex tears is to wash out irritants that may have come into contact with the eye whereas the blinking attempts to spread the lacrimal fluid over the ocular surface.

As a result of these reductions an increase in tear evaporation can occur. Therefore, dry-eye associated symptoms are extremely frequent in patients who underwent ocular surface surgery.

Dry eye may result infrequently in impaired wound healing and decreased optical quality of the cornea, but it is transient, lasting from a few weeks up to 1 year.

LIPITEARTM Action and Effect

LIPITEARTM is currently the only available eye drop with a clinically proven indication of corneal re-epithelization enhancement following mechanical, traumatic and surgical epithelial loss. Thanks to its composition, LIPITEARTM forms an elastic lipid shield. This protective shield restores the proper microenvironment for a healthy ocular surface, facilitating the physiological repairing processes arising from dry-eye, surgery and corneal erosions. LIPITEARTM is also efficient in restoring a uniform and smooth surface, with excellent optical properties.

1 Solomon, Kerry D., et al. “Refractive surgery survey 2001.” Journal of Cataract & Refractive Surgery 28.2 (2002): 346-355. About photorefractive keratectomy and laser in situ keratomileusis